Case study in Digital scale-up and optimization of microbial processes
Microbial fermentation processes
ONLINE COURSE: On-demand
COURSE FEE: 350 € per session
COURSE ORGANIZATION
Course organized in 7 sessions
Sessions can be taken individually
Scheduling: suggested one session per week
Effort: 4 - 8 hours per session
COURSE DESCRIPTION
This advanced course in fermentation engineering focusses on the digital scale-up and optimization of fermentation processes, through an in-depth case study of glutamic acid production. Participants will learn and apply methodologies in kinetic analysis, process modeling and simulation, scale-up strategies and optimal operational design. The course integrates upstream and downstream operations, aiming to maximize annual glutamate output or minimize production costs.
INSTRUCTOR
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Jean-Marc Engasser, BioProcess Digital
WHAT YOU'LL LEARN?
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Design and analyze experiments to determine the kinetics of microbial reaction and oxygen transfer
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Construct fermentors simulation models
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Use process simulators to scale up and optimize the microbial fermentor in batch and fed-batch modes for highest productivity or lowest production cost
DIGITAL LEARNING
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Learning platform with course resources
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Live or recorded slideshow videos
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Fermentation project on spreadsheet templates with self-corrections and guides
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Online collective or one-to-one tutoring
COURSE PROGRAM
SESSION 1: KINETIC ANALYSIS OF THE FERMENTATION
At the laboratory, evaluation of the rates of bacteria growth, sugar consumption, and metabolites production
SESSION 2: OXYGEN CONSUMPTION AND TRANSFER
At the laboratory, determination of the oxygen consumption rate, of the oxygen solubility and transfer rate
SESSION 3: FERMENTATION MODELING-SIMULATION
Modeling-simulation of the bacteria growth and metabolism in the laboratory batch fermentor
SESSION 4: BATCH FERMENTATION SCALE-UP AND PRODUCTION OPTIMIZATION
Scale-up of the fermentor simulation model. Optimization of the batch fermentation operation for highest production
SESSION 5: BATCH FERMENTATION COST OPTIMIZATION
Economic evaluation of the fermentation process. Optimization of the batch fermentation for lowest production cost
SESSION 6: FED-BATCH FERMENTATION OPTIMIZATION
Optimization the fed-batch fermentation for reduced co-metabolites production and lowest cost
SESSION 7: FERMENTATION INTENSIFICATION BY OXYGEN-ENRICHED AIR
Optimization of the fed-batch fermentor, aerated with oxygen-enriched air, for increased production