Digital scale-up and optimization of microbial fermentations
Fermentation engineering principles, kinetic analysis, knowledge simulation models, digital optimization of batch, continuous and fed-batch fermentations
ONLINE COURSE: On-demand
COURSE FEE: 350 € per session
COURSE ORGANIZATION
Course organized in 7 sessions
Sessions can be taken individually
Scheduling: suggested one session per week
Effort: 3 - 6 hours per session
COURSE DESCRIPTION
The course provides a comprehensive overview of the concepts and methodologies of bioprocess engineering for the digital design and optimization of microbial fermentations. It covers fermentation kinetics, oxygen transfer in fermentors, the development of knowledge-driven simulation models, the scale-up and optimal operations of batch, continuous, and fed-batch fermentations. The course combines methodological review presentations with industrial fermentations case studies.
INSTRUCTOR
-
Jean-Marc Engasser, BioProcess Digital
DIGITAL LEARNING
-
Learning platform with course resources
-
Live or recorded slideshow presentations
-
Case studies on spreadsheet templates with guides and corrections
-
Online collective or one-to-one tutoring
COURSE PROGRAM
SESSION 1: FERMENTATION ENGINEERING PRINCIPLES
Fermentations influencing phenomena. Microbial kinetics. Mass transfer in fermentors. Mass balances
SESSION 2: FERMENTATION KINETIC ANALYSIS
Kinetic analysis in batch and continuous fermentors. Fermentation and microbial rates. Kinetic laws
SESSION 3: OXYGEN TRANSFER AND CONSUMPTION KINETICS
Kinetic analysis of oxygen transfer and microbial uptake. Oxygen solubility and transfer rate laws
SESSION 4: FERMENTATION SIMULATION MODEL ON SPREADSHEET
Simulation model mass balances, thermodynamic and kinetic relations. Numerical integration on spreadsheet.
SESSION 5: BATCH FERMENTATIONS SIMULATION AND OPTIMIZATION
Batch fermentations principles. Operational variables optimization for maximum productivity
SESSION 6: CONTINUOUS FERMENTATIONS SIMULATION AND OPTIMIZATION
Continuous fermentations principles. Dynamic and steady-state kinetics. Operational variables optimization
SESSION 7: FED-BATCH FERMENTATIONS SIMULATION AND OPTIMIZATION
Fed-batch fermentations principles. Operational variables optimization for cells and metabolites production