Introduction to animal cell culture technology and engineering
Cells, media, bioreactors. Cell cultures kinetics, simulation, optimal operation
ONLINE COURSE: On-demand
COURSE FEE: 350 € per session
COURSE ORGANIZATION
Course organized in 3 sessions
Sessions can be taken independently
Scheduling: suggested one session per week
Effort: 2 - 3 hours per session
COURSE DESCRIPTION
This introductory course is designed for students and professionals new to the field of animal cell cultures. It offers a comprehensive overview of the technologies used to cultivate animal cells for the production of therapeutic cells, proteins and viruses. The course also introduces the core concepts and methods of bioprocess engineering used to simulate, scale-up and optimize cell culture processes for industrial applications.
INSTRUCTOR
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Jean-Marc Engasser, BioProcess Digital
DIGITAL LEARNING
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Learning platform with course resources
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Live or recorded slideshow presentations
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Simulations on spreadsheet templates
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Online collective or one-to-one tutoring
COURSE PROGRAM
SESSION 1: ANIMAL CELL CULTURES TECHNOLOGY
Industrial suspended and adherent cells. Nutritional requirements and culture media.
Cell culture bioreactors from laboratory to industrial scale.
Cell culture production processes with upstream and downstream purification operations.
SESSION 2: CELL CULTURES UNDERSTANDING AND SIMULATION
Cell cultures kinetics: cellular growth and death, consumption of nutrients, production of metabolites, proteins, viruses
Biological and physical phenomena influencing cultures: cellular reaction, oxygen transfer, medium flow.
Knowledge driven simulation models of cell cultures.
SESSION 3: OPTIMAL OPERATION OF CELL CULTURE BIOREACTORS
Optimization of cell bioreactors operation mode and variables
Fed-batch cultures for operation under substrates limitations
Perfusion cultures with retained and attached cells for high cell densities